CACNB1 (NM_199247) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 2
Synonyms
CAB1; CACNLB1; CCHLB1
Gene ID
782
UniProt
Q02641, Q02641-2
Accession Number mRNA
NM_199247
Chromosomal Location
17q12
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
Field of Research
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Ion Channels: Other
Molecular Weight
57.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CACNB1
Species
Human
Protein ID
NP_954855
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/782
Uniprot URL
https://www.uniprot.org/uniprot/Q02641
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_199247
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_954855
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