JAK3 (NM_000215) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease) . [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human Janus kinase 3 (a protein tyrosine kinase, leukocyte) (JAK3)

Synonyms

JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK

Gene ID

3718

UniProt

P52333, A0A024R7M7

Accession Number mRNA

NM_000215

Chromosomal Location

19p13.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Chemokine signaling pathway, Jak-STAT signaling pathway, Primary immunodeficiency

Field of Research

Chemokine signaling pathway, Jak-STAT signaling pathway, Primary immunodeficiency

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

124.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.