RBFOX1 (NM_018723) Human Recombinant Protein
Product Specifications
Background
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U) GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2) . Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Synonyms
2BP1; A2BP1; FOX-1; FOX1; HRNBP1
Gene ID
54715
UniProt
Q9NWB1, Q59HD3
Accession Number mRNA
NM_018723
Chromosomal Location
16p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
42.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RBFOX1
Species
Human
Protein ID
NP_061193
Overview
Recombinant protein of human ataxin 2-binding protein 1 (A2BP1), transcript variant 4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54715
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWB1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018723
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_061193
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
