XRCC4 (NM_022550) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V (D) J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED) . Alternate transcript variants such as NM_022406 are unlikely to be expressed in some individuals due to a polymorphism (rs1805377) in the last splice acceptor site. [provided by RefSeq, Oct 2019]
Synonyms
SSMED
Gene ID
7518
UniProt
Q13426, A0A024RAL0, Q7Z763
Accession Number mRNA
NM_022550
Chromosomal Location
5q14.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Non-homologous end-joining
Field of Research
Non-homologous end-joining
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
37.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
XRCC4
Species
Human
Protein ID
NP_072044
Overview
Recombinant protein of human X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7518
Uniprot URL
https://www.uniprot.org/uniprot/Q13426
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022550
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_072044
Curated Selection
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