WDR59 (NM_030581) Human Recombinant Protein
Product Specifications
Background
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238) . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human WD repeat domain 59 (WDR59)
Synonyms
CDW12; FP977; p90-120
Gene ID
79726
UniProt
Q6PJI9
Accession Number mRNA
NM_030581
Chromosomal Location
16q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
109.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
WDR59
Species
Human
Protein ID
NP_085058
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/79726
Uniprot URL
https://www.uniprot.org/uniprot/Q6PJI9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_030581
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_085058
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