DCC (NM_005215) Human Recombinant Protein
Product Specifications
Background
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Synonyms
CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1; NTN1R1
Gene ID
1630
UniProt
P43146, Q49AK4
Accession Number mRNA
NM_005215
Chromosomal Location
18q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Axon guidance, Colorectal cancer, Pathways in cancer
Field of Research
Axon guidance, Colorectal cancer, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
158.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DCC
Species
Human
Protein ID
NP_005206
Overview
Recombinant protein of human deleted in colorectal carcinoma (DCC)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1630
Uniprot URL
https://www.uniprot.org/uniprot/P43146
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005215
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005206
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