DCC (NM_005215) Human Recombinant Protein

Product Specifications

Background

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Overview

Recombinant protein of human deleted in colorectal carcinoma (DCC)

Synonyms

CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1; NTN1R1

Gene ID

1630

UniProt

P43146, Q49AK4

Accession Number mRNA

NM_005215

Chromosomal Location

18q21.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Axon guidance, Colorectal cancer, Pathways in cancer

Field of Research

Axon guidance, Colorectal cancer, Pathways in cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

158.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.