CHMP2A (NM_198426) Human Recombinant Protein
Product Specifications
Background
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs) . Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]) .[supplied by OMIM, Mar 2008]
Synonyms
BC-2; BC2; CHMP2; VPS2; VPS2A
Gene ID
27243
UniProt
O43633, A0A024R4S0
Accession Number mRNA
NM_198426
Chromosomal Location
19q13.43
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Endocytosis
Field of Research
Endocytosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
24.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CHMP2A
Species
Human
Protein ID
NP_940818
Overview
Recombinant protein of human chromatin modifying protein 2A (CHMP2A), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/27243
Uniprot URL
https://www.uniprot.org/uniprot/O43633
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_198426
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_940818
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