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INMT (NM_006774) Human Recombinant Protein

Product Specifications

Background

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]

Overview

Recombinant protein of human indolethylamine N-methyltransferase (INMT)

Synonyms

TEMT

Gene ID

11185

UniProt

O95050

Accession Number mRNA

NM_006774

Chromosomal Location

7p14.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Tryptophan metabolism

Field of Research

Tryptophan metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

28.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

INMT

Species

Human

Protein ID

NP_006765

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/11185

Uniprot URL

https://www.uniprot.org/uniprot/O95050

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006774

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006765

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