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DOPA Decarboxylase (DDC) (NM_001082971) Human Recombinant Protein

Product Specifications

Background

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) . AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

Synonyms

AADC

Gene ID

1644

UniProt

P20711, Q53Y41, A0A0S2Z3N4

Accession Number mRNA

NM_001082971

Chromosomal Location

7p12.2-p12.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism

Field of Research

Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

53.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DDC

Species

Human

Protein ID

NP_001076440

Overview

Recombinant protein of human dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1644

Uniprot URL

https://www.uniprot.org/uniprot/P20711

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001082971

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001076440

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