UBXN2B (NM_001077619) Human Recombinant Protein

Product Specifications

Background

Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156) . Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156) . The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156) . VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156) . Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807) . Also, regulates spindle orientation during mitosis (PubMed:23649807) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human UBX domain protein 2B (UBXN2B)

Synonyms

P37

Gene ID

137886

UniProt

Q14CS0

Accession Number mRNA

NM_001077619

Chromosomal Location

8q12.1

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

36.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.