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Epac1 (RAPGEF3) (NM_001098532) Human Recombinant Protein

Product Specifications

Background

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.[UniProtKB/Swiss-Prot Function]

Synonyms

Bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275

Gene ID

10411

UniProt

O95398, Q99777

Accession Number mRNA

NM_001098532

Chromosomal Location

12q13.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Leukocyte transendothelial migration, Long-term potentiation

Field of Research

Leukocyte transendothelial migration, Long-term potentiation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

99.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

RAPGEF3

Species

Human

Protein ID

NP_001092002

Overview

Recombinant protein of human Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 3

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/10411

Uniprot URL

https://www.uniprot.org/uniprot/O95398

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001098532

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001092002

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