SMURF1 (NM_181349) Human Recombinant Protein

Product Specifications

Background

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

Overview

Recombinant protein of human SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 2

Synonyms

KIAA1625

Gene ID

57154

UniProt

Q9HCE7

Accession Number mRNA

NM_181349

Chromosomal Location

7q22.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis

Field of Research

Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

83.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.