NIRF (UHRF2) (NM_152896) Human Recombinant Protein
Product Specifications
Background
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Overview
Recombinant protein of human ubiquitin-like with PHD and ring finger domains 2 (UHRF2)
Synonyms
NIRF; RNF107; TDRD23; URF2
Gene ID
115426
UniProt
Q96PU4
Accession Number mRNA
NM_152896
Chromosomal Location
9p24.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
89.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UHRF2
Species
Human
Protein ID
NP_690856
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/115426
Uniprot URL
https://www.uniprot.org/uniprot/Q96PU4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_152896
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_690856
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