PDE3B (NM_000922) Human Recombinant Protein

Product Specifications

Background

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human phosphodiesterase 3B, cGMP-inhibited (PDE3B)

Synonyms

CGIPDE1; HcGIP1

Gene ID

5140

UniProt

Q13370, A7E2E5

Accession Number mRNA

NM_000922

Chromosomal Location

11p15.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Insulin signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism

Field of Research

Insulin signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

124.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.