CNO6L (CNOT6L) (NM_144571) Human Recombinant Protein
Product Specifications
Background
Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.[UniProtKB/Swiss-Prot Function]
Synonyms
CCR4b
Gene ID
246175
UniProt
Q96LI5
Accession Number mRNA
NM_144571
Chromosomal Location
4q21.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
RNA degradation
Field of Research
RNA degradation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
62.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CNOT6L
Species
Human
Protein ID
NP_653172
Overview
Recombinant protein of human CCR4-NOT transcription complex, subunit 6-like (CNOT6L)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/246175
Uniprot URL
https://www.uniprot.org/uniprot/Q96LI5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_144571
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_653172
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