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Sterol carrier protein 2 (SCP2) (NM_002979) Human Recombinant Protein

Product Specifications

Background

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Overview

Recombinant protein of human sterol carrier protein 2 (SCP2), transcript variant 1

Synonyms

NLTP; NSL-TP; SCOX; SCP-2; SCP-CHI; SCP-X; SCPX

Gene ID

6342

UniProt

P22307, A0A384NY87, B2R761, Q59HG9

Accession Number mRNA

NM_002979

Chromosomal Location

1p32.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, PPAR signaling pathway, Primary bile acid biosynthesis

Field of Research

Metabolic pathways, PPAR signaling pathway, Primary bile acid biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

58.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SCP2

Species

Human

Protein ID

NP_002970

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6342

Uniprot URL

https://www.uniprot.org/uniprot/P22307

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002979

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002970

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