Liver Carboxylesterase 1 (CES1) (NM_001266) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Synonyms
ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
Gene ID
1066
UniProt
P23141
Accession Number mRNA
NM_001266
Chromosomal Location
16q12.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Drug metabolism - other enzymes
Field of Research
Drug metabolism - other enzymes
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
60.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CES1
Species
Human
Protein ID
NP_001257
Overview
Recombinant protein of human carboxylesterase 1 (monocyte/macrophage serine esterase 1) (CES1), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1066
Uniprot URL
https://www.uniprot.org/uniprot/P23141
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001266
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001257
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