Calcipressin 1 (RCAN1) (NM_004414) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Overview
Recombinant protein of human regulator of calcineurin 1 (RCAN1), transcript variant 1
Synonyms
ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
Gene ID
1827
UniProt
P53805
Accession Number mRNA
NM_004414
Chromosomal Location
21q22.12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
27.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RCAN1
Species
Human
Protein ID
NP_004405
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1827
Uniprot URL
https://www.uniprot.org/uniprot/P53805
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004414
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004405
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