Osteocalcin (BGLAP) (NM_199173) Human Recombinant Protein
Product Specifications
Background
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Synonyms
BGP; OC; OCN
Gene ID
632
UniProt
P02818
Accession Number mRNA
NM_199173
Chromosomal Location
1q22
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
ES Cell Differentiation/IPS, Secreted Protein
Molecular Weight
8.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BGLAP
Species
Human
Protein ID
NP_954642
Overview
Recombinant protein of human bone gamma-carboxyglutamate (gla) protein (BGLAP)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/632
Uniprot URL
https://www.uniprot.org/uniprot/P02818
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_199173
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_954642
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