RNF157 (NM_052916) Human Recombinant Protein
Product Specifications
Background
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469) . Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469) . May act as a scaffold molecule to regulate this process (PubMed:25342469) . Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764) .[UniProtKB/Swiss-Prot Function]
Gene ID
114804
UniProt
Q96PX1
Accession Number mRNA
NM_052916
Chromosomal Location
17q25.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
73.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RNF157
Species
Human
Protein ID
NP_443148
Overview
Purified recombinant protein of Homo sapiens ring finger protein 157 (RNF157)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/114804
Uniprot URL
https://www.uniprot.org/uniprot/Q96PX1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_052916
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_443148
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