Leucyl cystinyl aminopeptidase (LNPEP) (NM_005575) Human Recombinant Protein
Product Specifications
Background
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms
CAP; IRAP; P-LAP; PLAP
Gene ID
4012
UniProt
Q9UIQ6
Accession Number mRNA
NM_005575
Chromosomal Location
5q15
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Renin-angiotensin system
Field of Research
Renin-angiotensin system
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease, Secreted Protein, Transmembrane
Molecular Weight
117.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LNPEP
Species
Human
Protein ID
NP_005566
Overview
Recombinant protein of human leucyl/cystinyl aminopeptidase (LNPEP), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4012
Uniprot URL
https://www.uniprot.org/uniprot/Q9UIQ6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005575
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005566
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