NUMB (NM_001005743) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Overview

Recombinant protein of human numb homolog (Drosophila) (NUMB), transcript variant 1

Synonyms

C14orf41; c14_5527; S171

Gene ID

8650

UniProt

P49757, A0A024R6F4

Accession Number mRNA

NM_001005743

Chromosomal Location

14q24.2-q24.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Notch signaling pathway

Field of Research

Notch signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

70.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.