NUMB (NM_001005743) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Synonyms
C14orf41; c14_5527; S171
Gene ID
8650
UniProt
P49757, A0A024R6F4
Accession Number mRNA
NM_001005743
Chromosomal Location
14q24.2-q24.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Notch signaling pathway
Field of Research
Notch signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
70.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NUMB
Species
Human
Protein ID
NP_001005743
Overview
Recombinant protein of human numb homolog (Drosophila) (NUMB), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8650
Uniprot URL
https://www.uniprot.org/uniprot/P49757
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001005743
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001005743
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