CHRNA2 (NM_000742) Human Recombinant Protein

Product Specifications

Background

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]

Overview

Recombinant protein of human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2)

Synonyms

Cholinergic receptor, nicotinic, alpha 2 (neuronal) ; cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) ; OTTHUMP00000128276

Gene ID

1135

UniProt

Q15822

Accession Number mRNA

NM_000742

Chromosomal Location

8p21.2

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane

Molecular Weight

56.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.