Smek1 (PPP4R3A) (NM_032560) Human Recombinant Protein
Product Specifications
Background
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human SMEK homolog 1, suppressor of mek1 (Dictyostelium) (SMEK1)
Synonyms
FLFL1; KIAA2010; MSTP033; PP4R3A; smk-1; smk1
Gene ID
55671
UniProt
Q6IN85
Accession Number mRNA
NM_032560
Chromosomal Location
14q32.12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
93.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SMEK1
Species
Human
Protein ID
NP_115949
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55671
Uniprot URL
https://www.uniprot.org/uniprot/Q6IN85
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032560
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115949
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