Tryptophan Hydroxylase (TPH1) (NM_004179) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
Overview
Recombinant protein of human tryptophan hydroxylase 1 (TPH1)
Synonyms
TPRH; TRPH
Gene ID
7166
UniProt
P17752
Accession Number mRNA
NM_004179
Chromosomal Location
11p15.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Tryptophan metabolism
Field of Research
Metabolic pathways, Tryptophan metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
50.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TPH1
Species
Human
Protein ID
NP_004170
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7166
Uniprot URL
https://www.uniprot.org/uniprot/P17752
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004179
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004170
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