ZGPAT (NM_181485) Human Recombinant Protein
Product Specifications
Background
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human zinc finger, CCCH-type with G patch domain (ZGPAT), transcript variant 3
Synonyms
GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
Gene ID
84619
UniProt
Q8N5A5, A0A0S2Z5X3
Accession Number mRNA
NM_181485
Chromosomal Location
20q13.33
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
55.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ZGPAT
Species
Human
Protein ID
NP_852150
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84619
Uniprot URL
https://www.uniprot.org/uniprot/Q8N5A5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_181485
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_852150
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