ZGPAT (NM_181485) Human Recombinant Protein

Product Specifications

Background

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human zinc finger, CCCH-type with G patch domain (ZGPAT), transcript variant 3

Synonyms

GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP

Gene ID

84619

UniProt

Q8N5A5, A0A0S2Z5X3

Accession Number mRNA

NM_181485

Chromosomal Location

20q13.33

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

55.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.