Progesterone Receptor (PGR) (NM_000926) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Overview
Recombinant protein of human progesterone receptor (PGR)
Synonyms
NR3C3; PR
Gene ID
5241
UniProt
P06401
Accession Number mRNA
NM_000926
Chromosomal Location
11q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Oocyte meiosis, Progesterone-mediated oocyte maturation
Field of Research
Oocyte meiosis, Progesterone-mediated oocyte maturation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Molecular Weight
98.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PGR
Species
Human
Protein ID
NP_000917
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5241
Uniprot URL
https://www.uniprot.org/uniprot/P06401
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000926
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000917
Frequently Asked Questions
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