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Progesterone Receptor (PGR) (NM_000926) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Overview

Recombinant protein of human progesterone receptor (PGR)

Synonyms

NR3C3; PR

Gene ID

5241

UniProt

P06401

Accession Number mRNA

NM_000926

Chromosomal Location

11q22.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Oocyte meiosis, Progesterone-mediated oocyte maturation

Field of Research

Oocyte meiosis, Progesterone-mediated oocyte maturation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Molecular Weight

98.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PGR

Species

Human

Protein ID

NP_000917

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5241

Uniprot URL

https://www.uniprot.org/uniprot/P06401

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000926

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000917

Frequently Asked Questions

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