C15ORF27 (TMEM266) (NM_152335) Human Recombinant Protein
Product Specifications
Background
Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529) . Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529) . Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529) . Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529) .[UniProtKB/Swiss-Prot Function]
Synonyms
C15orf27; HsHVRP1; hTMEM266; HVRP1
Gene ID
123591
UniProt
Q2M3C6
Accession Number mRNA
NM_152335
Chromosomal Location
15q24.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
58.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TMEM266
Species
Human
Protein ID
NP_689548
Overview
Recombinant protein of human chromosome 15 open reading frame 27 (C15orf27)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/123591
Uniprot URL
https://www.uniprot.org/uniprot/Q2M3C6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_152335
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_689548
Curated Selection
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