Alpha Synuclein (SNCA) (NM_007308) Human Recombinant Protein
Product Specifications
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Synonyms
NACP; PARK1; PARK4; PD1
Gene ID
6622
UniProt
P37840, H6UYS5
Accession Number mRNA
NM_007308
Chromosomal Location
4q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Parkinson's disease
Field of Research
Alzheimer's disease, Parkinson's disease
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
11.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SNCA
Species
Human
Protein ID
NP_009292
Overview
Recombinant protein of human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant NACP112
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6622
Uniprot URL
https://www.uniprot.org/uniprot/P37840
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007308
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_009292
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