PANK1 (NM_138316) Human Recombinant Protein
Selected Variant
PH34426M5
Size: 20 µg
Product Specifications
Background
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA) . The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636) . [provided by RefSeq, Apr 2011]
Overview
Recombinant protein of human pantothenate kinase 1 (PANK1), transcript variant gamma
Synonyms
PANK
Gene ID
53354
UniProt
Q8TE04
Accession Number mRNA
NM_138316
Chromosomal Location
10q23.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Pantothenate and CoA biosynthesis
Field of Research
Metabolic pathways, Pantothenate and CoA biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
35.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PANK1
Species
Human
Protein ID
NP_612189
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/53354
Uniprot URL
https://www.uniprot.org/uniprot/Q8TE04
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_138316
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_612189
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