Caspase-7 (CASP7) (NM_001227) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Overview
Recombinant protein of human caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha
Synonyms
CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Gene ID
840
UniProt
P55210
Accession Number mRNA
NM_001227
Chromosomal Location
10q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Apoptosis
Field of Research
Alzheimer's disease, Apoptosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
34.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CASP7
Species
Human
Protein ID
NP_001218
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/840
Uniprot URL
https://www.uniprot.org/uniprot/P55210
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001227
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001218
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