Caspase-7 (CASP7) (NM_033338) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Overview

Purified recombinant protein of Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant delta

Synonyms

CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3

Gene ID

840

UniProt

P55210

Accession Number mRNA

NM_033338

Chromosomal Location

10q25.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Apoptosis

Field of Research

Alzheimer's disease, Apoptosis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

37.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.