NCBP2 (NM_001042540) Human Recombinant Protein
Product Specifications
Background
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CBC2; CBP20; NIP1; PIG55
Gene ID
22916
UniProt
P52298
Accession Number mRNA
NM_001042540
Chromosomal Location
3q29
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Spliceosome
Field of Research
Spliceosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
11.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NCBP2
Species
Human
Protein ID
NP_001036005
Overview
Purified recombinant protein of Homo sapiens nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/22916
Uniprot URL
https://www.uniprot.org/uniprot/P52298
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001042540
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001036005
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