DRP1 (DNM1L) (NM_012062) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) . Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Overview

Recombinant protein of human dynamin 1-like (DNM1L), transcript variant 1

Synonyms

DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV; OPA5

Gene ID

10059

UniProt

O00429, B4DYR6

Accession Number mRNA

NM_012062

Chromosomal Location

12p11.21

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Endocytosis, Fc gamma R-mediated phagocytosis

Field of Research

Endocytosis, Fc gamma R-mediated phagocytosis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

25853493

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

81.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.