CPEB4 (NM_030627) Human Recombinant Protein

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967) . RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967) . Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity) . Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195) . Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752) . Stimulates proliferation of melanocytes (PubMed:27857118) . In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.