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PCB (PC) (NM_000920) Human Recombinant Protein

Product Specifications

Background

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Synonyms

PCB

Gene ID

5091

UniProt

P11498, A0A024R5C5

Accession Number mRNA

NM_000920

Chromosomal Location

11q13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Citrate cycle (TCA cycle), Metabolic pathways, Pyruvate metabolism

Field of Research

Citrate cycle (TCA cycle), Metabolic pathways, Pyruvate metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

127.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PC

Species

Human

Protein ID

NP_000911

Overview

Recombinant protein of human pyruvate carboxylase (PC), nuclear gene encoding mitochondrial protein, transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5091

Uniprot URL

https://www.uniprot.org/uniprot/P11498

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000920

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000911

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