Plexin A1 (PLXNA1) (NM_032242) Human Recombinant Protein
Product Specifications
Background
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
NOV; NOVP; PLEXIN-A1; PLXN1
Gene ID
5361
UniProt
Q9UIW2
Accession Number mRNA
NM_032242
Chromosomal Location
3q21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Axon guidance
Field of Research
Axon guidance
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
210.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PLXNA1
Species
Human
Protein ID
NP_115618
Overview
Recombinant protein of human plexin A1 (PLXNA1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5361
Uniprot URL
https://www.uniprot.org/uniprot/Q9UIW2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032242
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115618
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