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Flt3 ligand (FLT3LG) (NM_001459) Human Recombinant Protein

Selected Variant

PH34250M5

Size: 20 µg

Product Specifications

Background

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910) -positive classical DCs and their CD103 (ITGAE; MIM 604682) -positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]) .[supplied by OMIM, Jan 2011]

Overview

Recombinant protein of human fms-related tyrosine kinase 3 ligand (FLT3LG)

Synonyms

FL; FLG3L; FLT3L

Gene ID

2323

UniProt

P49771

Accession Number mRNA

NM_001459

Chromosomal Location

19q13.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer

Field of Research

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

FLT-3LG generate dendritic cell differentiation: Fms-like tyrosine kinase 3 ligand (Flt3L) is a nonredundant cytokine required for dendritic cell (DC) homeostasis in lymphoid tissues. FLT3L is commonly used to generate pDCs in vitro.In this experiment, 300,000 unfractioned mouse bone marrow cells were cultured with purified recombinant human FLT-3L (Leading Biology, PH34250M5) at indicated concentrations. Total live cells were counted at the day 8.

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane

Molecular Weight

26.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FLT3LG

Species

Human

Protein ID

NP_001450

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2323

Uniprot URL

https://www.uniprot.org/uniprot/P49771

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001459

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001450

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