LRRC8C (NM_032270) Human Recombinant Protein
Product Specifications
Background
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) ; channel characteristics depend on the precise subunit composition.[UniProtKB/Swiss-Prot Function]
Synonyms
AD158; FAD158
Gene ID
84230
UniProt
Q8TDW0
Accession Number mRNA
NM_032270
Chromosomal Location
1p22.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
92.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LRRC8C
Species
Human
Protein ID
NP_115646
Overview
Recombinant protein of human leucine rich repeat containing 8 family, member C (LRRC8C)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84230
Uniprot URL
https://www.uniprot.org/uniprot/Q8TDW0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032270
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115646
Curated Selection
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