TRAF4AF1 (KNSTRN) (NM_033286) Human Recombinant Protein
Product Specifications
Background
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759) . Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139) . The astrin (SPAG5) -kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792) . Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123) . May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257) .[UniProtKB/Swiss-Prot Function]
Synonyms
C15orf23; HSD11; SKAP; TRAF4AF1
Gene ID
90417
UniProt
Q9Y448
Accession Number mRNA
NM_033286
Chromosomal Location
15q15.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
35.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KNSTRN
Species
Human
Protein ID
NP_150628
Overview
Recombinant protein of human chromosome 15 open reading frame 23 (C15orf23), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/90417
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y448
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_033286
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_150628
Curated Selection
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