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ABL2 (NM_001100108) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Overview

Recombinant protein of human v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) (ABL2), transcript variant c

Synonyms

ABLL; ARG; FLJ22224; FLJ31718; FLJ41441

Gene ID

27

UniProt

P42684

Accession Number mRNA

NM_001100108

Chromosomal Location

1q25.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

ErbB signaling pathway, Viral myocarditis

Field of Research

ErbB signaling pathway, Viral myocarditis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

126.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ABL2

Species

Human

Protein ID

NP_001093578

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/27

Uniprot URL

https://www.uniprot.org/uniprot/P42684

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001100108

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001093578

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