CD10 (MME) (NM_007287) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

Overview

Recombinant protein of human membrane metallo-endopeptidase (MME), transcript variant 1bis

Synonyms

CALLA; CD10; CMT2T; NEP; SCA43; SFE

Gene ID

4311

UniProt

P08473

Accession Number mRNA

NM_007287

Chromosomal Location

3q25.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

Field of Research

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease, Transmembrane

Molecular Weight

85.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.