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Aminoadipate aminotransferase (AADAT) (NM_016228) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Synonyms

KAT2; KATII; KYAT2

Gene ID

51166

UniProt

Q8N5Z0, Q4W5N8

Accession Number mRNA

NM_016228

Chromosomal Location

4q33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysine biosynthesis, Lysine degradation, Metabolic pathways, Tryptophan metabolism

Field of Research

Lysine biosynthesis, Lysine degradation, Metabolic pathways, Tryptophan metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

The specific activity of KATII was determined by measuring the product Kynurenic acid formation from a conversion of Kynurenine. The reaction was carried out at 37? for 15min in the buffer containing PBS, pH7.4, 2mM a-oxoglutarate, 40µM PLP (pyridoxal 5'-phosphate), and 0.5mM kynurenine as the substrate.

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

47.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

AADAT

Species

Human

Protein ID

NP_057312

Overview

Recombinant protein of human aminoadipate aminotransferase (AADAT), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/51166

Uniprot URL

https://www.uniprot.org/uniprot/Q8N5Z0

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_016228

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_057312

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