XPF (ERCC4) (NM_005236) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6) .[provided by RefSeq, Mar 2009]

Overview

Recombinant protein of human excision repair cross-complementing rodent repair deficiency, complementation group 4 (ERCC4)

Synonyms

ERCC11; FANCQ; RAD1; XFEPS; XPF

Gene ID

2072

UniProt

Q92889, A0A1W1GSK9

Accession Number mRNA

NM_005236

Chromosomal Location

16p13.12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Nucleotide excision repair

Field of Research

Nucleotide excision repair

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

104.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.