DIABLO (NM_138930) Human Recombinant Protein
Product Specifications
Background
This gene encodes an inhibitor of apoptosis protein (IAP) -binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Overview
Purified recombinant protein of Homo sapiens diablo homolog (Drosophila) (DIABLO), nuclear gene encoding mitochondrial protein, transcript variant 2
Synonyms
DFNA64; SMAC
Gene ID
56616
UniProt
Q9NR28, Q502X2
Accession Number mRNA
NM_138930
Chromosomal Location
12q24.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
21.7
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DIABLO
Species
Human
Protein ID
NP_620308
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/56616
Uniprot URL
https://www.uniprot.org/uniprot/Q9NR28
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_138930
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_620308
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