TCF4 (NM_001083962) Human Recombinant Protein
Product Specifications
Background
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
Synonyms
BHLHb19; CDG2T; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4
Gene ID
6925
UniProt
P15884, B3KVA4
Accession Number mRNA
NM_001083962
Chromosomal Location
18q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Molecular Weight
71.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TCF4
Species
Human
Protein ID
NP_001077431
Overview
Recombinant protein of human transcription factor 4 (TCF4), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6925
Uniprot URL
https://www.uniprot.org/uniprot/P15884
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001083962
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001077431
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