Neurofilament (NEFM) (NM_005382) Human Recombinant Protein
Product Specifications
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Synonyms
NEF3; NF-M; NFM
Gene ID
4741
UniProt
P07197
Accession Number mRNA
NM_005382
Chromosomal Location
8p21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Amyotrophic lateral sclerosis (ALS)
Field of Research
Amyotrophic lateral sclerosis (ALS)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
102.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NEFM
Species
Human
Protein ID
NP_005373
Overview
Recombinant protein of human neurofilament, medium polypeptide (NEFM), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4741
Uniprot URL
https://www.uniprot.org/uniprot/P07197
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005382
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005373
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