Neurofilament (NEFM) (NM_005382) Human Recombinant Protein

Product Specifications

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Overview

Recombinant protein of human neurofilament, medium polypeptide (NEFM), transcript variant 1

Synonyms

NEF3; NF-M; NFM

Gene ID

4741

UniProt

P07197

Accession Number mRNA

NM_005382

Chromosomal Location

8p21.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Amyotrophic lateral sclerosis (ALS)

Field of Research

Amyotrophic lateral sclerosis (ALS)

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

102.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.