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MPP5 (NM_022474) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Overview

Recombinant protein of human membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (MPP5)

Synonyms

PALS1

Gene ID

64398

UniProt

Q8N3R9, Q658X5

Accession Number mRNA

NM_022474

Chromosomal Location

14q23.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Tight junction

Field of Research

Tight junction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

77.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MPP5

Species

Human

Protein ID

NP_071919

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/64398

Uniprot URL

https://www.uniprot.org/uniprot/Q8N3R9

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_022474

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_071919

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