MPP5 (NM_022474) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Synonyms
PALS1
Gene ID
64398
UniProt
Q8N3R9, Q658X5
Accession Number mRNA
NM_022474
Chromosomal Location
14q23.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Tight junction
Field of Research
Tight junction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
77.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MPP5
Species
Human
Protein ID
NP_071919
Overview
Recombinant protein of human membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (MPP5)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64398
Uniprot URL
https://www.uniprot.org/uniprot/Q8N3R9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022474
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071919
Curated Selection
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