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CD11d (ITGAD) (NM_005353) Human Recombinant Protein

Product Specifications

Background

This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Overview

Recombinant protein of human integrin, alpha D (ITGAD)

Synonyms

ADB2; CD11D

Gene ID

3681

UniProt

Q13349, Q59H14

Accession Number mRNA

NM_005353

Chromosomal Location

16p11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Regulation of actin cytoskeleton

Field of Research

Regulation of actin cytoskeleton

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

124.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ITGAD

Species

Human

Protein ID

NP_005344

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3681

Uniprot URL

https://www.uniprot.org/uniprot/Q13349

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005353

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005344

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