CTBP2 (NM_001329) Human Recombinant Protein

Product Specifications

Background

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Overview

Recombinant protein of human C-terminal binding protein 2 (CTBP2), transcript variant 1

Synonyms

C-terminal binding protein 2; OTTHUMP00000020699; OTTHUMP00000020701; ribeye

Gene ID

1488

UniProt

P56545

Accession Number mRNA

NM_001329

Chromosomal Location

10q26.13

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Chronic myeloid leukemia, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

Field of Research

Chronic myeloid leukemia, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Stem cell - Pluripotency, Stem cell relevant signaling - Wnt Signaling pathway

Molecular Weight

48.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.